May 15, 2024 · Myeloid-derived suppressor cells (MDSCs) are known to suppress antitumor immune responses, and the effect of natural killer (NK) cells on their development has been unclear. Here, Neo et al. have identified an inflammatory gene signature that correlated with higher NK cell abundance in nonresponders to immune checkpoint blockade.

This review discusses MDSC-mediated NK cell regulation within the TME, focusing on critical cellular and molecular interactions. We review current strategies that target MDSC-mediated immunosuppression to enhance NK cell cytotoxic antitumor activity.

NK cells have been shown to play a fundamental role in haploidentical hemopoietic stem cell transplantation (HSCT), for the therapy of high-risk leukemias. A deeper analysis of MDSC functional effects demonstrated that these cells are capable, through several mechanisms, to reduce the potent GvL activity exerted by NK cells.

Jul 1, 2022 · This review discusses MDSC-associated immunosuppression, the mechanisms regulating communication between MDSCs and NK cells in the tumor microenvironment, and how MDSC may impact NK-cell-based immunotherapies.

May 15, 2024 · Apart from their killer identity, natural killer (NK) cells have integral roles in shaping the tumor microenvironment. Through immune gene deconvolution, the present study revealed an interplay between NK cells and myeloid-derived suppressor cells (MDSCs) in nonresponders of immune checkpoint therap …

Cryo-thermal therapy induces effective CD4 + Th1-dominant antitumor immunity by activating NK cells to reprogram MDSCs, providing a promising therapeutic strategy for cancer immunotherapy.

Natural killer (NK) cells can engage in crosstalk with multiple myeloid cells to alter adaptive immune responses, triggering T-cell immunity. However, whether the NK-cell-MDSC interaction can modulate the T-cell immune response requires further study.

May 8, 2014 · CD16xCD33 BiKE potently activates blood and marrow MDS-NK cells at all diseases stages to lyse CD33 + MDS and CD33 + MDSC targets. Myelodysplastic syndromes (MDS) are stem cell disorders that can progress to acute myeloid leukemia.

Here, we review whether the crosstalk between MDSCs and NK cells can impact on tumor onset, angiogenesis and progression, focusing on key cellular and molecular interactions.

Feb 12, 2021 · NK cells have been shown to play a fundamental role in haploidentical hemopoietic stem cell transplantation (HSCT), for the therapy of high-risk leukemias. A deeper analysis of MDSC functional effects demonstrated that these cells are capable, through several mechanisms, to reduce the potent GvL activity exerted by NK cells.