This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway.

Mar 3, 2002 · We also describe a novel pathway by which MAPK activation via NIK regulates NF-κB activation in human melanoma cells.

Dec 19, 2016 · Although the role of NF-κB-inducing kinase (NIK) in immunity is well established, its relevance in cancer is just emerging. Here we describe novel functions for NIK in regulating mitochondrial dynamics and motility to promote cell invasion.

Jun 7, 2023 · In this review, we outline the specific regulatory mechanisms of MAP3Ks in antiviral immunity and discuss the feasibility of targeting MAP3Ks for the treatment of virus-induced diseases.

Aug 9, 2018 · Activation of IKK is typically mediated by transforming growth factor beta-activated kinase 1 (TAK1), a MAPK kinase kinase (MAP3K) that responds to various immune receptor signals and relies on ubiquitination for its catalytic activation and signaling function (19, 20).

Aug 2, 2018 · Here, we identify Map3k14 (also known as NIK) and its substrate Chuk (also called IKKα) as unrecognized suppressors of hepatocyte replication. Chronic liver disease is associated with aberrant activation of hepatic NIK pathways.

Apr 3, 2019 · NF-κB-inducing kinase (NIK; also known as MAP3K14) is a central regulator of non-canonical NF-κB signaling in response to stimulation of TNF receptor superfamily members, such as the lymphotoxin-β receptor (LTβR), and is implicated in pathological angiogenesis associated with chronic inflammation an …

Mar 26, 2019 · NF-κB inducing kinase [NIK (also known as MAP3K14)] is best known as the apical kinase that triggers non-canonical NF-κB activation and as a key regulator of the immune response because inactivating Nik/NIK mutations cause the alymphoplasia (aly) phenotype in mice and immunodeficiency in humans .

Oct 19, 2020 · Conditional NIK-mutant mice and bone marrow chimeric mice have revealed the cell-specific functions of NIK 245,246,247. Broad deletion of Map3k14 in adult mice recapitulates the B cell effects...

Mar 8, 2002 · Furthermore, using wild type and kinase-dead mutant constructs of NIK, we have shown that NIK activity is required for the induction of NF-κβ promoter activity in melanoma cells. We also describe a novel pathway by which MAPK activation via NIK regulates NF-κB activation in human melanoma cells.