Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA, cytokine production and cell survival.

Jul 14, 2017 · NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells. Innate immune cells, including macrophages, dendritic cells...

Mar 4, 2024 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the interaction...

Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation, differentiation, and survival.

Dec 8, 2009 · After gaining access to the nucleus, NF-κB must be actively regulated to execute its fundamental function as a transcription factor. Recent studies have highlighted the importance of nuclear...

Nuclear factor kappa B (NFκB) is a family of dimeric transcription factors central to coordinating inflammatory responses; innate and adaptive immunity; and cellular differentiation, proliferation, and survival in almost all multicellular organisms. 1 – 4 The NFκB system is tightly regulated, and misregulation of NFκB has been implicated in a wi...

It plays important roles in the control of immune function, inflammation, stress response, differentiation, apoptosis, and cell survival. Moreover, NF-kappaB is critically involved in the processes of development and progression of cancers.

Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation.

NFkappaB was identified 20 years ago (Sen, R., & Baltimore, D. (1986) Cell, 46, 705-716) as a nuclear factor that binds the kappa light chain enhancer in B-cells (and hence, the name NFkappaB) and was shown to play roles in innate and adaptive immune responses.

NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells. Innate immune cells, including macrophages, dendritic cells and neutrophils, are important players of innate immunity and inflammation.