Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber ...
Mar 5, 2016 · To induce HIF-1α stabilization, we used a loss of function strategy to abrogate Prolyl hydroxylase domain protein (PHD) 2 responsible for HIF-1α hydroxylation making HIF …
The RCAN1.4-calcineurin/NFAT signaling pathway is essential
May 29, 2020 · Another study showed that prolyl hydroxylase domain 2 (PHD2) deficiency, which contributed to the limited oxygen-dependent degradation of HIF-1α and might serve as a …
PHD2 deficiency induces slow muscle fiber type switching in the …
In this study, we investigated whether tacrolimus modulates tumor necrosis factor (TNF)-mediated axonal degeneration and whether it alters nuclear factor of activated T... ... In the nucleus of...
NFAT - Wikipedia
Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of …
NFAT2 Isoforms Differentially Regulate Gene Expression, Cell …
Several studies have suggested the oncogenic potential of the NFAT family member NFAT2. NFAT2 was fundamental for pancreatic cancer progression and contributed to the survival of …
18018 - Gene ResultNfatc1 nuclear factor of activated T cells ...
Feb 8, 2025 · These results demonstrate the role of calcineurin-NFAT pathway in lymphangiogenesis and suggest that NFATc1 is the principle NFAT involved. MEF2 and MITF …
NFAT signaling in neural development and axon growth
NFAT transcriptional activity has been shown to be stimulated by an influx of Ca 2+ through L-type channels in cultured hippocampal neurons (Graef, Mermelstein et al. 1999).
TCL-330 RHOA G17V Potentiates CD28-Induced NFAT …
Sep 1, 2023 · Collectively, these findings reveal an unexpected role for RHOA G17V in potentiating CD28 T195P-induced NFAT transcriptional activity through the modulation of …
NFAT Signaling - Cell Press
Apr 19, 2002 · CsA prevented NFAT-dependent transcription and endothelial migration as well as the activation of specific endothelial genes such as Cyclooxygenase-2 (Cox-2). Blocking NFAT …
Phd2 deletion induces angiogenesis in skeletal muscle. a The …
PHD2 deficiency can activate the calcineurin/NFATc1dependent pathway 21, indicating that HIF-1α is possibly involved in activating the calcineurin/NFATc1 pathway. We found elevated...