Sep 11, 2017 · NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection.

Feb 17, 2015 · During persistent antigen stimulation, CD8 (+) T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors …

NFAT proteins induce a transcriptional program of CD8 + T cell exhaustion. An engineered NFAT that cannot cooperate with AP-1 strongly induces exhaustion. The engineered NFAT1 blunts …

Dec 12, 2024 · To examine factors downstream of TCR signaling, we focused on nuclear factor of activated T cells (NFAT), a transcription factor that orchestrates CD8 + T cell activation and …

Jun 30, 2022 · Dapl1 controls activation of NFATc2, a transcription factor required for the effector function of CD8 + T cells. Although NFATc2 mediates induction of the immune checkpoint …

Aug 9, 2023 · GSK3 regulates TCR-mediated NFAT activation in activated CD8 + T cells. NFAT is a crucial regulator of T-cell exhaustion, and NFAT-binding sites in genes encoding negative …

Sep 11, 2017 · Nfatc1 -/-, but not Nfatc2 -/-CD8 + T cells have an impaired metabolic switch to glycolysis, which can be restored by IL-2. Genome-wide ChIP-seq shows that NFATc1 binds …

Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8 + T cells in the context of chronic infections and …

Feb 17, 2015 · We defined the genomic regions occupied by endog-enous and engineered NFAT1 in primary CD8+ T cells and showed that genes directly induced by the engi-neered …

During persistent antigen stimulation, CD8 + T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections. …