Apr 30, 2001 · Concomitant induction of NFAT and AP-1 requires concerted activation of two different signaling pathways: calcium/calcineurin, which promotes NFAT dephosphorylation, …

May 14, 2019 · Envisioning a strategy for selective modulation of the immune response, we designed a FRET-based high-throughput screen to identify compounds that disrupt the …

The effects of the AP-1 transcription factors, associated with the immune system, are largely mediated through combinatorial regulation with the NFAT, a calcium/calcineurin pathway …

Apr 30, 2001 · The four calcium-regulated transcription factors of the NFAT family act synergistically with AP-1 (Fos/Jun) proteins on composite DNA elements which contain …

Jun 1, 2005 · In activated T cells, NFAT proteins synergize with activator protein 1 (AP1) transcription factors at composite sites that are located in the promoters and enhancers of …

We show that Compound 10 disrupts the NFAT:AP-1 interaction at several but not all composite NFAT:AP-1 sites, without inhibiting the binding of NFAT or Fos-Jun dimers to DNA; and that it …

Aug 20, 2010 · It was soon recognized that NFAT contained both nuclear and cytoplasmic constituents 2. The nuclear component was identified as the activator protein 1 (AP1) …

Tetraspanin CD81 provides a costimulatory signal resulting in increased human immunodeficiency virus type 1 gene expression in primary CD4+ T lymphocytes through NF-kappaB, NFAT, and …

Transcription factors of the nuclear factor of activated T cell (NFAT) family are essential for antigen-specific T cell activation and differentiation. Their cooperative DNA binding with other …

Apr 24, 2019 · We show that Compound 10 disrupts the NFAT:AP-1 interaction at several but not all composite NFAT:AP-1 sites, without inhibiting the binding of NFAT or Fos-Jun dimers to …