Mammalian myotube dedifferentiation induced by newt ... - PubMed
Nov 20, 2001 · To investigate the causes underlying the lack of cellular plasticity in mammalian cells, we examined the effect of an extract derived from newt regenerating limbs on terminally …
- Author: Christopher J. McGann, Shannon J. Odelberg, Mark T. Keating
- Publish Year: 2001
An adult myogenic cell line of the Japanese fire-bellied newt
Dec 3, 2024 · Adult myogenic cell lines are useful to study muscle development, repair and regeneration. In newts, which are known for their high regenerative capacity, myogenic cell …
Mammalian myotube dedifferentiation induced by …
Nov 20, 2001 · To investigate the causes underlying the lack of cellular plasticity in mammalian cells, we examined the effect of an extract derived from newt regenerating limbs on terminally differentiated mouse C2C12 myotubes.
Newts, a urodele amphibian belonging to the family Salamandridae, have an exceptionally high regenerative capacity among tetrapods, endowing them with the ability to regenerate various …
Restoring the Cell Cycle and Proliferation Competence in …
The newt, a urodele amphibian, is among the best studied examples. Newts can regenerate virtually any part of their bodies, after injury. In these animals, the skeletal muscle, as well as …
MyoD is a 3D genome structure organizer for muscle cell identity
Jan 11, 2022 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the …
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Trunk muscle differentiation—a lesson from the Chinese fire …
Mar 1, 2025 · Here, we describe larval myotomal myogenesis in the Chinese fire-bellied newt, Hypselotriton orientalis. Morphological, ultrastructural, cytochemical, and …
MyoD, a Lesson in Widespread DNA Binding - Cell Press
Apr 20, 2010 · MyoD is a classic master regulator that commits those somite cells in which it is expressed to a myoblast fate and also later activates skeletal muscle genes during the …
Stage-specific effects of Notch activation during …
Sep 19, 2016 · Activation of Notch1 in MyoD Cre lineage (Timing 1, T1) blocks differentiation, promotes self-renewal of SCs, which causes absence of skeletal musculature and embryonic lethality; Activation of Notch1 in MLC Cre lineage …
MyoD-Induced Trans-Differentiation: A Paradigm for Dissecting …
The discovery of the skeletal muscle-specific transcription factor MyoD represents a milestone in the field of transcriptional regulation during differentiation and cell-fate reprogramming. MyoD …
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