Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts.

Jun 23, 2014 · Nucleotide excision repair (NER) eliminates structurally diverse DNA lesions by repairing helix-distorting damage throughout the genome as well as transcription-blocking lesions.

Here I will review the nucleotide excision repair (NER) pathway, a versatile mechanism that removes helix-distorting DNA lesions and structures from the genome. Several other dedicated pathways that have evolved to deal with different classes of lesions or non-canonical forms of DNA will be addressed in other sections in this volume.

Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky DNA lesions such as those formed by UV light, environmental mutagens, and some cancer chemotherapeutic adducts from DNA.

Nucleotide excision repair (NER) is the most versatile DNA repair pathway, which can remove diverse bulky DNA lesions destabilizing a DNA duplex. NER defects cause several autosomal recessive genetic disorders.

Excision repair is named because it is a type of DNA repair mechanism in which the unwanted bases are directly excised by the combination of enzymes and replaced by the new DNA. The excision repair can be employed for different lengths like a …

Nucleotide excision repair is a versatile DNA repair system that removes a wide variety of bulky and helix-distorting lesions. In NER, two distinct mechanisms exist, global genome repair and transcription-coupled repair.

Base excision repair (BER) and nucleotide excision repair (NER) are two major DNA excision repair systems. They follow a complex repair pathway in eukaryotes whereas a prototype system exists in prokaryotes.

In nucleotide excision repair or NER, the damaged base along with a short stretch of healthy strand is removed and later the gap is refilled with correct nucleotides. Thus the NER pathway operates by ‘cut and patch’ mechanism.

Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a multiwise 'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway prevents mutagenesis by probing the genome for helix-distorting lesions, whereas transcription-coupled NER (TC-NER) removes t …