Neli HEVIR, Scientist | Cited by 758 | of Lek Pharmaceuticals, Ljubljana | Read 26 publications | Contact Neli HEVIR

Estrogens have important roles in endometrial cancer (EC) and exert biological effects through the classical estrogen receptors (ERs) ERα and ERβ, and the G-protein–coupled ER, GPER. So far, the co-expression of these three types of ERs has not been studied in EC.

Apr 14, 2020 · Neli Hevir practices in Menges, Slovenia. Her top areas of expertise are Endometrial Cancer and Endometriosis. Her clinical research consists of co-authoring 11 peer reviewed articles in the past 15 years.

Jun 5, 2015 · To characterize model cell lines of endometrial cancer, we determined the expression profiles of the estrogen receptors (ERs) ESR1, ESR2 and GPER, and 23 estrogen biosynthetic and metabolic genes, and investigated estrogen biosynthesis in the control HIEEC cell line and the Ishikawa and HEC-1A EC cell lines.

Jun 23, 2017 · Sulfotransferase SULT1E1 catalyzes conjugation of estrogens and our previous studies show that gene encoding this enzyme is not differentially expressed in EC as compared to adjacent control tissue (Hevir et al., 2011b), while Lepine et al., reported borderline increased mRNA levels in cancer tissue (Lepine et al., 2010).

Feb 3, 2023 · Estrogens have important roles in endometrial cancer (EC) and exert biological effects through the classical estrogen receptors (ERs) ERα and ERβ, and the G-protein-coupled ER, GPER. So far, the co-expression of these three types of ERs has not been studied in EC.

Oct 5, 2010 · Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. by Neli Hevir, Jasna Sinkovec, Tea Lanišnik Rižner.

Feb 25, 2013 · First, we examined the expression of genes encoding proteins associated with progesterone biosynthesis: steroidogenic acute regulatory protein (STAR); a side chain cleavage enzyme (CYP11A1); and 3β-hydroxysteroid dehydrogenase/ketosteroid isomerase (HSD3B).

Aug 1, 2014 · Increased local concentrations of estrogens are a well-known risk factor for endometrial cancer development. Estrogens can act as mitogens via estrogen receptors, and by forming oxidative...

May 30, 2011 · Semantic Scholar extracted view of "Expression of estrogen and progesterone receptors and estrogen metabolizing enzymes in different breast cancer cell lines." by N. Hevir et al.