In addition, the MIR22HG/miRNA-10a-5p/NCOR2 axis inhibited the activation of the Wnt/β-catenin pathway. Together, our results demonstrated that MIR22HG inhibited HCC progression in part through the miR-10a-5p/NCOR2 signaling axis and might act as a new prognostic biomarker for HCC patients.

Large-scale investigations have identified several critical genes and multiple signaling pathways that are important for CRC initiation and progression, including WNT, Notch, p53, RAS-MAPK, PI3K and TGF-β. The WNT/β-catenin signaling pathway is the most studied in CRC [9].

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor -interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions.

Apr 7, 2009 · Our experiments define the COUP-TFII/SMRT complex as a previously unappreciated component of the linear pathway that directly links Wnt/beta-catenin signaling to repression of PPARgamma gene expression and the inhibition of adipogenesis.

Reiterative RA, Wnt and BMP signaling controls developmental competence and lineage specification in the developing gut tube. Wnt/BMP-mediated gastrula patterning impacts how endoderm tissue responds to subsequent Wnt/BMP-mediated lineage induction.

Feb 23, 2019 · We also demonstrated that MIR22HG regulated the Wnt/β‐catenin signaling pathway by targeting NCOR2, and knockdown of MIR22HG increased epithelial markers but decreased mesenchymal markers. These data demonstrated that MIR22HG suppressed EMT by modulating the Wnt/β‐catenin pathway.

Feb 2, 2016 · We have identified a new gene, NCOR2, in the retinoic acid signalling pathway pointing to a role of vitamin A metabolism in the regulation of FVC. Our findings also support SERPINE2, a COPD gene with weak previous evidence of association with FVC, and suggest WNT16 as a further promising candidate.

Dec 3, 2020 · a MIR22HG negatively regulates the Wnt/β-catenin signaling pathway by downregulating the expression of β-catenin, cyclin D1 and c-myc to inhibit cell proliferation and migration in CCA. b MIR22HG blocks the SMAD complex, preventing its binding to the promoter of SNAI1 and further suppressing the EMT signaling pathway.

Oct 1, 2016 · Our studies support a model in which NCOR1/2 mediates direct RA-dependent repression of Fgf8 in caudal progenitors in order to control somitogenesis. Keywords: Caudal progenitors, somitogenesis, nuclear receptor corepressor, NCOR, SMRT, Fgf8, Retinoic acid response element, CRISPR/Cas9 gene editing. 1. Introduction.

In cells with a low level of corepressors SMRT and NCoR or aberrant cytoplasmic localization (left), Wnt signals enable the accumulation of -catenin in the nucleus, where it binds to TCF4,...