They are suitable for use in applications related to xenotransplantation. <br /><br />To order this model with CD34+ or PBMC engraftment, please visit our <a href="https://www.jax.org/jax-mice-and-services/in-vivo-pharmacology/humanized-mice">Humanized Mice page</a>.

Feb 16, 2024 · Overall, NBSGW mice showed better survival and higher body weight than the NSG mice, allowing for more reliable blood sampling, easier administration of agents, and providing enhanced reliability for the long-term follow-up (Figure 1 B-C).

We demonstrate that nonirradiated NBSGW mice are similar in chimerism to that achieved in irradiated NSG (irNSG) mice and that NBSGW mice also support the serial transplantation of HSCs.

In this study, we address this challenge by using HSPC-NBSGW mice, in which NOD,B6.SCID IL-2r γ -/- Kit W41/W41 (NBSGW) mice are engrafted with human CD133 + hematopoietic stem and progenitor cells (HSPCs) without the need for preconditioning by sublethal irradiation.

Jul 18, 2024 · We aimed to build on the humanization of immunodeficient genetically myeloablated KitW-41J mutant NBSGW and NSGW41 mice 2, 3 by using a modified grafting and hormonal conditioning protocol to...

To generate an NSG TM -derivative strain that does not require myeloablative irradiation, the Thompson team bred NSG TM with C57BL/6J- KitW-41J /J (000119) mice.

Feb 27, 2024 · In vivo hematopoietic stem cell (HSC) gene therapy is an emerging and promising area of focus in the gene therapy field. Humanized mouse models are frequently used to evaluate novel HSC gene therapy approaches. Here, we comprehensively evaluated 2 mouse strains, NSG …

Feb 10, 2015 · At 12-weeks postengraftment in NBSGW mice, we observe human cell chimerism in marrow (97% ± 0.4%), peripheral blood (61% ± 2%), and spleen (94% ± 2%) at levels observed with irradiation in NSG mice.

Nov 15, 2022 · The KIT -deficient mouse strains NBSGW and NSGW41 have already been shown to provide improved engraftment of cord blood and support of human erythropoiesis compared to NSG mice.

Oct 19, 2020 · NBSGW mice are highly immunodeficient and carry a hypomorphic mutation in the c-kit gene, providing a host environment that supports robust human hematopoietic expansion without pre-conditioning. These mice thus provide a model to investigate human hematopoietic engraftment in the absence of conditioning-associated damage.