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Feb 21, 2025 · Mammalian neurophysiology vitally depends on the stable functioning of transmembrane, pore-forming voltage-sensing proteins known as voltage-gated sodium channels (NaVChs).

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Voltage-gated sodium channels (NavChs) are pore-forming membrane proteins that regulate the transport of sodium ions through the cell membrane. Understanding the structure and function of NavChs is of major biophysical, as well as clinical, importance given their key role in cellular pathophysiology.

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Apr 23, 2021 · Voltage-gated sodium channels (NaVChs) are pore-forming proteins embedded in cell membranes. They are members of the ion channels superfamily and their main physiological role is to control transport of sodium ions into the cell.