May 27, 2016 · MK886 abolished the ability of NAMPT knockdown to decrease intracellular cholesterol levels to enhance the rate of 3 H-cholesterol efflux and to increase ABCA1/G1 and LXRα expressions in RAW264.7...

Apr 22, 2022 · Here, we report the discovery of a chemical class of NAMPT activator (NAT) that has the ability to promote the proliferation of neural stem cells in vitro and exhibit neuroprotective efficacy in...

Nicotinamide phosphoribosyl transferase (Nampt) is the rate-limiting enzyme in the NAD salvage pathway responsible for converting NAM to NAD to maintain cellular redox state. Activation of AMP-activated protein kinase (AMPK) increases SIRT activity by elevating NAD levels.

Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis.

Dec 13, 2023 · Nicotinamide phosphoribosyltransferase (NAMPT) plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic...

Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD + synthesis, and in skeletal muscle, NAD + is essential for muscle integrity. However, the underlying molecular mechanisms by which NAD + synthesis affects muscle health remain poorly understood.

Mar 30, 2025 · (A) NAMPT was immunoprecipitated with NAMPT antibody, and ubiquitination levels of NAMPT detected using anti-Ub antibodies after 4 h treatment of WT and GSDMD KO (GKO) THP-1 cells with 1 µg/mL LPS. NAMPT immunoprecipitants were immunoblotted (IB) with the indicated antibodies.

May 27, 2016 · We demonstrated that a specific NAMPT knockdown increased plasma HDL-C levels, reduced the plaque area of the total aorta en face and the cross-sectional aortic sinus, decreased macrophage number and apoptosis, and promoted RCT in HFD-fed ApoE KO mice.

Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the salvage NAD + synthesis, is an interferon-inducible protein that inhibits the replication of several RNA and DNA viruses with unknown mechanism.

Mar 29, 2017 · Analysis of >200 offspring from a 2-step breeding protocol revealed close to expected Mendelian ratios for the predicted genotypes: 26.7% WT, 29.1% SMC-specific Nampt heterozygous, 20.6% Nampt heterozygous, and 23.5% SMC-Nampt knockout (KO).