Encouraging mitophagy may be a useful strategy to prevent CD8 + T cells from senescence due to mitochondrial dysfunction. Additionally, supplementing with NMN to increase NAD + levels could enhance survival rates in mice while also reducing senescence and inflammation, and enhancing mitophagy as a potential therapeutic intervention.

Here, we show that cell-autonomous generation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway (KP) contributes to the maintenance of intratumoral CD8+T cell metabolic and functional fitness. De novo NAD+ synthesis is involved in CD8+T cell metabolism and antitumor function.

Dec 26, 2023 · Our data highlight the neglected role of cell-autonomous NAD + synthesis in CD8 + T cell antitumor activity. Our findings also suggest that modulation of de novo NAD + synthesis could restore CD8 + T cell metabolic and functional fitness in the context of cancer immunotherapy.

Dec 3, 2023 · De novo NAD + synthesis is involved in CD8 + T cell metabolism and antitumor function. KP-derived NAD + promotes PTEN deacetylation, thereby facilitating PTEN degradation and preventing PTEN-dependent metabolic defects.

Herein, we discover that NAMPT-mediated NAD + metabolism enhances IFNγ-induced PD-L1 expression and drives tumor immune evasion in a CD8 + T cell-dependent manner.

Here we review potential roles of CD38 in health and disease and postulate ways in which CD38 dysregulation causes changes in NAD homeostasis and contributes to the pathophysiology of multiple conditions.

Jan 1, 2020 · We demonstrate that CD38 expression defines CD8 T cells that have limited cytotoxicity as well as cytotoxicity-related transcriptional factors through the NAD/Sirtuin1/EZH2 axis. We propose that it can be used to identify patients with higher propensity to develop infections and offers opportunities for therapeutic interventions.

Apr 7, 2025 · Nicotinamide adenine dinucleotide (NAD +) is a coenzyme essential for cellular energy metabolism , involved in nucleotide metabolism . Banerjee et ... further promoting CD8 + T cell proliferation and activation [219,220,221,222,223,224,225].

Apr 1, 2025 · While most CD8 + T cells are unable to upregulate lactylation modifications in response to exogenous lactate, ... Huang H, et al. Lactate enhances NMNAT1 lactylation to sustain nuclear NAD + salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions. Cancer Lett. 2024;588:216806.

Jan 7, 2020 · We propose that high levels of CD38 lead to decreased CD8 T cell-mediated cytotoxicity and increased propensity to infections in patients with SLE, a process that can be reversed pharmacologically. Keywords: CD38; CD8 T cell; EZH2; Sirtuin1; cytotoxicity; infection; nicotinamide adenine dinucleotide; patients; systemic lupus erythematosus.