Dec 11, 2017 · Here we show that the levels of an N-terminal proteolytically derived fragment of HDAC4, termed HDAC4-NT, are lower in failing mouse hearts than in healthy control hearts.

Jun 14, 2019 · We show that the cardio-protective N-terminal proteolytic fragment of HDAC4 is enhanced in vivo in patients with diabetes mellitus and mouse models, as well as in vitro under …

Here, we explored the function of HDAC4‐NT (1‐289aa, 1‐326aa and 1‐669aa) in chondrocytes and cartilage. The results showed that the HDAC4‐NT fragment 1‐669aa promoted …

The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates cardiac gene expression. Here we show that the levels of an N-terminal proteolytically derived …

Cardiac OE of HDAC4-NT (N-terminus) by intravenous injection of AAV9 with the cytomegalovirus (CMV)-enhanced myosin light chain promoter (Myl2) protected against the heart failure on …

Here, we identified a histone deacetylase 4 (HDAC4) subdomain as a molecular checkpoint of adaptive and maladaptive signaling in the diabetic heart. METHODS: A conditional HDAC4 …

The main achievement of HDACs on histones is to repress transcription and promote the formation of more compact chromatin. There are 18 different HDACs encoded in the human …

Exogenous administration of the histone deacetylation 4 (HDAC4) protein can effectively delay osteoarthritis (OA) progression. However, HDAC4 is unstable and easily degrades into N …

HDAC4 is unique among class IIa HDACs in responding to both PKA and CaMKII3,7. HDAC4 is proteolytically processed by a PKA-dependent mechanism to yield an N-terminal fragment …

Nov 15, 2019 · Consequently, HDAC4-NT functions as a potent signal-resistant inhibitor of MEF2 transcriptional activity, and ectopic expression of HDAC4-NT in the mouse heart has been …