Research shows that abnormal gene regulation during development contributes to some of the features of Wolf-Hirschhorn syndrome. A chromosomal rearrangement (translocation) …

Probable histone-lysine N-methyltransferase NSD2 is an enzyme that in humans is encoded by the NSD2 gene. [5][6][7] This gene encodes a protein that contains several domain types …

Mar 30, 2025 · NSD2 (Nuclear Receptor Binding SET Domain Protein 2) is a Protein Coding gene. Diseases associated with NSD2 include Rauch-Steindl Syndrome and Wolf-Hirschhorn …

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Mar 15, 2023 · Nuclear receptor-binding SET domain 2 (NSD2) is a histone lysine methyltransferase (HKMTase), which is mainly responsible for the di-methylation of lysine …

The NSD family of H3K36 methyltransferase enzymes—including NSD1 (KMT3B), NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1)—are now receiving drug development attention, …

Herein, we discuss the role of NSD2 in these pathological processes, and we review the most recent findings in the development of new compounds aimed against the oncogenic forms of …

Nov 2, 2023 · NSD2 mutations within the catalytic SET domain are frequently identified in lymphoid malignancies including acute lymphoblastic leukemia (ALL), chronic lymphocytic …

May 9, 2022 · We summarize the current understanding of the biological functions of NSD proteins, focusing on their activities and the role in the formation and progression in solid …

May 3, 2021 · NSD2 is the principal enzyme that dimethylates histone H3 at lysine 36 (H3K36me2) 11 in most cell types and tissues. 21 H3K36me2 is an evolutionarily conserved …