The gene is 1,112,187 bases in length, is located on the Crick (minus) strand and encodes a protein of 1,477 amino acids (molecular weight 161.883 kDa). Mutations of this gene that …

Mar 30, 2025 · NRXN1 (Neurexin 1) is a Protein Coding gene. Diseases associated with NRXN1 include Chromosome 2P16.3 Deletion Syndrome and Pitt-Hopkins-Like Syndrome 2. Among …

NRXN1 -related disorders are uncommonly reported. The clinical features of the disorders are wide and heterogeneous mainly consisting of undistinctive facial dysmorphism, mild to severe …

We present a medical record review of subjects with deletions involving exonic sequences of NRXN1. We ascertained cases from 3,540 individuals referred clinically for comparative …

The spectrum of phenotypes associated with heterozygous deletions of neurexin-1 (NRXN1) is diverse and includes: autism spectrum disorder, attention deficit hyperactivity disorder, …

Gene ID: 9378, updated on 8-Feb-2025. This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind …

Jan 5, 2025 · Gene target information for NRXN1 - neurexin 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Neurexins, including NRXN1, are cell-surface receptors that bind neuroligins (see NLGN1; 600568) to form a Ca (2+)-dependent neurexin/neuroligin complex at synapses in the central …

Dec 3, 2023 · Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This …

Jun 24, 2023 · De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical …