Targeting NQO1 induces ferroptosis and triggers anti-tumor …
Nov 1, 2024 · We identified NAD (P)H Quinone Dehydrogenase 1 (NQO1) as a transcriptional target of nuclear factor erythroid 2–related factor 2 (NRF2) and revealed that inducing NQO1 …
The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ...
Deletion of NQO1, a quinone/CoQ oxidoreductase proposed to function in ferroptosis 20, did not affect sensitivity to RSL3, but cells lacking both FSP1 and NQO1 (FSP1 KO /NQO1 KO) were …
NAD(P)H-quinone oxidoreductase 1 induces complicated effects …
Following treatment with rotenone, overexpressed NQO1 in SH-SY5Y cells improved cell survival by reducing mitochondrial reductive stress via increased NAD + supply without mitochondrial …
Translational Potential of Baicalein in Mitigating RSL3-Induced ...
May 13, 2024 · Detection of Keap1/Nrf2/NQO1 & HO-1 activation using western blotting in fibroblasts treated with PBS as a control or treated with 0.5 μM RSL3 in the presence or …
RSL3 induces ferroptosis by activating the NF-κB signalling …
Jan 25, 2025 · Interfering with the microtubule structure and function of tumour cells can prevent normal mitosis, thereby inhibiting the proliferation and spread of cancer cells. RSL3 is an …
Quantitative proteomic analyses reveal that GPX4 ... - Nature
Nov 4, 2019 · Depletion or inhibition of GPX4 using specific siRNA or the chemical inhibitor RSL3, respectively, resulted in the accumulation of lipid peroxide, leading to cell death by ferroptosis …
Tanshinone functions as a coenzyme that confers gain of function …
Mechanistically, we found that tanshinone functions as a coenzyme for NAD (P)H:quinone oxidoreductase 1 (NQO1), which detoxifies lipid peroxyl radicals and inhibits ferroptosis both in …
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS …
We investigated the effect of RSL3 (a selective ferroptosis inducer) on the viability of three different CRC cells and found RSL3 triggered ferroptotic cell death in a dose- and time …
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis …
Genetic and pharmacological inhibition of SCD1 confirms the essentiality of this gene and augments the effects of ferroptosis induction by erastin and RSL3. Together these data …
Role of NQO1 in ferroptosis resistance a, Western blot analysis of ...
Our results showed that artesunate subconjunctival injection alleviated bleb fibrosis by inhibiting fibroblast activation and inducing ferroptosis.
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