Nucleophosmin 1 Mutations in Acute Myeloid Leukemia - PMC
NPM1 contributes to the p53 stress response by modulating the activity and stability of p53 and the Arf tumor suppressor protein. NPM1 interacts directly with p53, regulating an increase in …
AML-Related NPM Mutations Drive p53 Delocalization into the …
A mutation of the NPM1 gene resulting in the altered C-terminus of NPM and aberrant localization of mutated NPM to the cytoplasm appears in approximately 50% AML with normal karyotype …
Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 …
Dec 22, 2016 · This study reveals a new STAT5 signaling pathway regulating p53 expression via NPM1 and uncovers new therapeutic targets for anticancer treatment in tumors driven by …
A redox mechanism underlying nucleolar stress sensing by ... - Nature
Nov 25, 2016 · Compared with wild-type NPM1 that can disrupt the p53–HDM2 interaction, the C275S mutant greatly compromises the activation of p53, highlighting that nucleoplasmic …
TP53/NPM1-mutated acute myeloid leukemia as a molecularly …
May 28, 2021 · NPM1+/TP53+ AML had more mutations in recurrently mutated genes (4.5 vs 2.1; P < 0.0001) than TP53+/NPM1- AML. Conclusions: TP53+/NPM1+ AML harbors molecular …
Nucleophosmin: from structure and function to disease …
Aug 24, 2016 · These observations provide evidence that NPM1 regulates cell fate in a p53-dependent manner by directing p14 ARF to nucleoli and preventing inhibition of MDM2 (Fig. 4) …
Functions of the native NPM1 protein and its leukemic mutant
Dec 17, 2024 · In unstressed cells, p14ARF and NPM1 form a dimer in the nucleoli, allowing MDM2 to target p53 causing its nuclear export and proteasomal degradation, which allows to …
P53: A key player in diverse cellular processes including nuclear ...
Aug 1, 2024 · Nucleophosmin 1 (NPM1) is a multifunctional protein that plays a pivotal role in various cellular processes, including ribosome biogenesis, centrosome duplication, and …
Oncogene c-fos and mutant R175H p53 regulate expression of
Aug 7, 2018 · We show here that the expression of NPM1 is regulated by transcription factor c-fos, a protein that is strongly activated by growth factor signals. In addition, mutant p53 …
AML-Related NPM Mutations Drive p53 Delocalization into the ... - PubMed
Jun 29, 2021 · Nucleophosmin (NPM) interaction with tumor suppressor p53 is a part of a complex interaction network and considerably affects cellular stress response. The impact of …