Sep 10, 2018 · Here, we show that loss of NPM1c from the cytoplasm, either through nuclear relocalization or targeted degradation, results in immediate downregulation of homeobox …

Oct 8, 2020 · Because pharmacologic XPO1 inhibition also potently downregulates HOX expression in NPM1-mutated AML, 74 we envision synchronized inhibition of menin-MLL and …

Mar 7, 2024 · In this review we summarize molecular mechanisms underlying HOX regulation in clinical subsets of AML, with a focus on NPM1 mutated (NPM1 mut) AML comprising a third of …

Nov 1, 2019 · Higher expression of the HOX genes was identified in tumors harboring NPM1 gene mutations by computationally linking genotype and gene expression. In vitro validation of these …

Nov 25, 2019 · In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1 -mutated (NPM1 mut) acute myeloid leukemia (AML). We show that HOXB-AS3 …

Oct 23, 2024 · In this study, we investigated the subcellular localization and leukemogenic potential of two rare NPM1-fusion proteins, NPM1::MLF1 and NPM1::CCDC28A. NPM1::MLF1 …

Oct 8, 2020 · NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministically to cause the aberrant …

Here, we show that loss of NPM1c from the cytoplasm, either through nuclear relocalization or targeted degradation, results in immediate downregulation of homeobox (HOX) genes followed …

NPM1 mutations are among the most common genetic events in AML and their role in leukemogenesis is still obscure. Here, we show that HOX expression, differentiation levels, …

Here, we show that loss of NPM1c from the cytoplasm, either through nuclear relocalization or targeted degradation, results in immediate down-regulation of homeobox (HOX) genes …