A “grappling hook” interaction connects self-assembly and …
Jan 6, 2023 · The crystal structure of NPM1 120 shows side-by-side and end-to-end association of NTD pentamers in a crystal lattice via salt bridges (Fig. S2b), which leads us to speculate …
Clinical Relevance of NPM1 Quantitative PCR As Standard of Care …
Nov 5, 2024 · Regardless of time periods for MRD assessment, NPM1 qPCR provided excellent prognostic risk stratification: p=0.05 on day 0-120, p<0.0001 on day 121-240, and P<0.0001 …
Functions of the native NPM1 protein and its leukemic mutant
Dec 17, 2024 · NPM1 is mutated in about 30–35% of adult acute myeloid leukemia (AML). Due to its unique biological and clinical features, NPM1 -mutated AML is regarded as a distinct …
Nucleophosmin mutations in acute myeloid leukemia: A tale of …
Feb 25, 2013 · In this review, we focus on the leukemia-associated NPM1 C-terminal domain and describe its structure, function, and the effect exerted by leukemic mutations. Finally, we …
NPM1 -mutated acute myeloid leukemia: from bench to bedside
Oct 8, 2020 · NPM1 mutations represent the most common genetic lesion in adult acute myeloid leukemia (AML; about one third of cases), and they act deterministically to cause the aberrant …
Recent advances in AML with mutated NPM1 | International
Aug 22, 2024 · Recent studies have revealed various clinical applications of NPM1 mutations in AML treatment, particularly in measurable residual disease analyses that target mutant NPM1 …
Significance of NPM1 Gene Mutations in AML - PMC - PubMed …
The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal …
NPM1 delays A 42 aggregation. (a) NPM1 has a modular
(c) The presence of increasing amounts of NPM1 shows that NPM1 delays the onset and the elongation of fibrillation, as judged by ThT fluorescence. Error bars indicate the standard …
A0A0S2Z491 - UniProt
Feb 17, 2016 · UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.
A grappling hook interaction balances self-assembly and …
Sep 29, 2022 · Nucleophosmin 1 (NPM1) is an abundant nucleolar protein that forms large oligomers which provide the scaffold for ribosome assembly but also prevent protein …