Jan 7, 2025 · Here, we demonstrate that knockout of Npc1 in hepatocytes attenuates hepatocellular carcinoma (HCC) progression in both DEN (diethylnitrosamine)-CCl 4 induced and MYC-driven HCC mouse models....

Nov 15, 2024 · Through in vitro experiments, we found that inhibiting NPC1 expression reduced the proliferation, invasion, and migration of liver cancer cells, while also inducing apoptosis in these cells. Additionally, the inhibition of NPC1 led to decreased activation of …

NPC1 Antibody. Applications: WB, IHC, ELISA, ICC/IF, IP. Reactivity: Human, Mouse, Rat, Hamster, Non-human primate. Publications: 28. Images: 43. Clonality: Polyclonal, Monoclonal, Recombinant Monoclonal. Conjugates: Unconjugated, Biotin, FITC.

Jul 21, 2021 · Here, through a spatiotemporally resolved proximity labelling screen followed by quantitative proteomics, we identify the lysosomal membrane protein Niemann–Pick type C1 (NPC1) as a cofactor in...

5 days ago · Monoclonal Antibody for studying NPC1. Validated for IF, IHC, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, NPC1 (E7S4N) Rabbit Monoclonal Antibody (CST #33422) is ready to ship.

Dec 20, 2024 · Our analysis of transcriptomic and proteomic databases has identified increased mRNA and protein expression levels of NPC1, a cholesterol intracellular transporter protein, in hepatocellular carcinoma tissues. This increase is significantly …

Tested in Western Blot (WB), Immunocytochemistry (ICC/IF), Immunohistochemistry (Paraffin) (IHC (P)), Immunoprecipitation (IP) and Immunomicroscopy (IM) applications. This antibody reacts with Hamster, Human, Mouse, Non-human primate, Porcine, Rat samples.