Jul 1, 2011 · NADPH oxidase-4 (Nox4) is an important modulator of redox signaling that is inducible at the level of transcriptional expression in multiple cell types. By contrast to other Nox enzymes, Nox4 is continuously active without requiring stimulation.

Nrf2 controls the basal and induced expression of an array of antioxidant response element–dependent genes to regulate the physiological and pathophysiological outcomes of oxidant exposure. This review discusses the impact of Nrf2 on oxidative stress and toxicity and how Nrf2 senses oxidants and regulates antioxidant defense.

Jul 1, 2011 · One potential target and effector of ROS signaling is the cap ‘n’ collar basic leucine zipper transcription factor, Nrf2. Nrf2 acts as a positive transcriptional regulator of a battery of genes involved in antioxidant and xenobiotic defense systems .

Both Nrf1 and Nrf2 are responsible for regulating the expression of many antioxidant genes including peroxiredoxin-1 (Prx-1), thioredoxin-1 (Txn-1), GCLC (Glutamate cysteine ligase catalytic subunit - an enzyme responsible for catalyzing the formation of glutathione), glutathione peroxidase (GPX-1), drug metabolizing enzymes (cytochrome P-450s ...

Nrf2 −/− retinas exhibited an increase in VEGF but also induction of anti-angiogenic Dll4-Notch signaling. NADPH oxidase (NOX), and especially NOX2, is a major pathogenic molecule and a particularly important contributor to oxidative stress in multiple retinal disease processes.

Macrophages activate the cytoprotective factor Nrf2 upon phagocytic ROS production via PI3K-calcium-Nox signaling during immune surveillance. This protective response is crucial to sustain vital immune functions and limit macrophage acquisition of senescence-like features.

The aim of this study was to investigate a possible correlation between lung tissue NOX4 and Nrf2 genes (NOX4 and Nrf2) mRNA expression and bronchoalveolar lavage fluid (BALF) protein expression in non-small-cell lung carcinoma (NSCLC) patients.

Conclusions: These observations suggest that the Keap1-Nrf2 pathway regulates both mitochondrial and cytosolic ROS production through NADPH oxidase. General significance: Findings supports a key role of the Keap1-Nrf2 pathway in redox homeostasis within the cell. Keywords: Keap1; NADPH oxidase; NOX; Nrf2; ROS. Copyright © 2014.

Feb 1, 2022 · ROS activates Nrf2 transcript factor by protein translation or protein stabilization. Nrf2 increases Mfn2, PINK1, p62, PGC-1α, NResF1 and mitochondrial gene expression. Nrf2 aids in regulation of mitochondrial hyerfusion, mitophagy and biogenesis. Nrf2 inducers show mitochondrial protection in animal models of cardiac injury.

Jul 14, 2022 · Nox4 overexpressing CAFs depend on the Nrf2 (nuclear factor-erythroid factor 2-related factor 2) pathway for survival. We then determined the dependency of Nox4-overexpressing CAFs on the Nrf2-mediated adaptive stress response pathway for survival.