May 11, 2024 · Here we capture motions of full-length human NOX5 upon calcium binding using single-particle cryogenic electron microscopy (cryo-EM). By combining biochemistry, mutagenesis analyses, and...

Aug 30, 2017 · To examine the possibility that NOX5‐related ROS might contribute to enhanced genetic instability of UACC‐257 cells, we evaluated the activation of phosphorylated γH2AX, a biomarker for DNA damage and repair.

Aug 14, 2020 · Proposed Model of Membranous NOX5-derived local ROS oxidizes and activates Src to promote growth and invasion of ESCC cells.

Together with the phagocyte NADPH oxidase itself (NOX2/gp91(phox)), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).

Knockdown of Nox5-S with siRNA decreased ROS production in esophageal adenocarcinoma cells, dramatically inhibited cellular proliferation, and promoted apoptosis. Nox5-derived ROS also increases the expression of cyclooxygenase 2 which increases the proliferation of adenocarcinoma cells via the synthesis of prostaglandin E2 .

NOX5 generates superoxide (O 2 •−) using NADPH as a substrate, and it modulates functions related to processes in which reactive oxygen species (ROS) are involved. Those functions appear to be detrimental or beneficial depending on the level of ROS produced.

In physiological conditions, NOX5‐induced ROS generation seems to be important in the regulation of sperm motility, smooth muscle contraction and lymphocyte function, and in pathological conditions it has been implicated in cardiovascular …

Jul 8, 2016 · NOX5 protein, one of the most active generators of reactive oxygen species (ROS), plays an important role in many processes, including regulation of cell growth, death and differentiation. Because of its central role in ROS generation, it needs to be tightly regulated to guarantee cellular homeostas …

Jul 8, 2016 · NOX5 protein from the family of NADPH-oxidases is one of the most active generators of reactive oxygen species (ROS), which plays an important role in numerous physiological and pathophysiological processes, such as …

Aug 1, 2024 · NOX5, being a calcium-regulated professional ROS source exerts its function at the crossroad of these two fundamental but potentially deleterious intracellular signaling pathways (i.e. Ca 2+ and ROS).