NOX2 is an isoform from NADPH oxidase expressed in platelets and an important regulator of platelet activation-associated thrombosis. The present article aims to highlight the relative …

Oct 11, 2019 · Here, we combined exercise in humans and mice with fluorescent dyes, genetically-encoded biosensors, and NADPH oxidase 2 (NOX2) loss-of-function models to …

NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB …

Although NOX2-mediated ROS generation promotes glucose oxidation, a metabolic-dependent feedback loop allows glycolysis to increase the expression of NOX2 and p47 phox to improve …

Together with the phagocyte NADPH oxidase itself (NOX2/gp91 (phox)), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to …

Oct 15, 2011 · NOX2-derived ROS have been shown to suppress antigen-dependent T-cell reactivity and remarkably to reduce the severity of experimental arthritis in both rats and mice. …

In this review, we summarize recent progress regarding immune regulation by NOX2-derived ROS and the consequences of its deregulation on the development of immune disorders. …

Oct 14, 2022 · NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces superoxide (O 2•−), a key reactive oxygen species (ROS) that is essential in innate …

NOX2, activated by TNFα, thrombin or NF-κB-induced ROS, promotes migration and angiogenesis via the Akt and cSrc pathways. NOX2-mediated regulation of angiogenesis also …

Aug 28, 2010 · The NOX2 NADPH oxidase in particular has been assigned multiple roles, functioning as a source of antimicrobial ROS, an activator of many signaling pathways, a …