NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). [5] The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).

Although NOX2-mediated ROS generation promotes glucose oxidation, a metabolic-dependent feedback loop allows glycolysis to increase the expression of NOX2 and p47 phox to improve the ability of macrophages to produce ROS.

Together with the phagocyte NADPH oxidase itself (NOX2/gp91(phox)), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).

Oct 14, 2022 · NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces superoxide (O 2•−), a key reactive oxygen species (ROS) that is essential in innate and adaptive immunity.

Together with the phagocyte NADPH oxidase itself (NOX2/gp91 phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).

Redox signaling in cells by reactive oxygen species (ROS) occurs mainly through hydrogen peroxide (H 2 O 2) promoting S-glutathionylation and/or the reversible oxidation of cysteine thiol groups.

Neutrophils and macrophages utilize NOX2-derived ROS during the oxidative burst, which is characterized by ROS release into the lumen of phagosomes at very high rates and eventually leads to destruction of internalized pathogens [, , ].

Jan 20, 2023 · Among the ROS, the superoxide anion radical (O2·-) is a key redox signaling molecule prominently generated by the NADPH oxidase (NOX) enzyme family and by the mitochondrial electron transport chain.

Aug 28, 2010 · Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases were identified as one of the key sources of ROS in immune cells.

NOX2 is an isoform from NADPH oxidase expressed in platelets and an important regulator of platelet activation-associated thrombosis. The present article aims to highlight the relative contribution of NOX2 as a key target of different platelet …