NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in …

Nov 23, 2012 · NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II …

NLRC5 is a member of the NLR family that acts as a transcriptional activator of MHC class I genes. In line with the function of several related NLR proteins in innate immune responses, …

NLRC5 plays a regulatory role in inflammatory response, innate immune response, and antiviral response. It was reported that NLRC5 could combine with RIG-I and MDA5 to encompass IFN …

NLRC5, the largest member of the NLR protein family, has recently been identified as a critical regulator of immune responses. While NLRC5 is constitutively and widely expressed, it can be …

May 22, 2012 · Recent intensive studies, largely in vitro, on NLRC5 reveal multiple and controversial roles of this NLR protein in signaling regulation of both innate and adaptive …

NOD-, LRR- and CARD-containing 5 (NLRC5) was recently identified as a specific transactivator of MHC class I genes (CITA). NLRC5 and the master regulator for MHC class II genes, class II …

Mar 30, 2025 · NLRC5 (NLR Family CARD Domain Containing 5) is a Protein Coding gene. Diseases associated with NLRC5 include Pityriasis Rubra Pilaris and Familial Pityriasis Rubra …

Mar 27, 2023 · In contrast to CIITA, the N-terminus of NLRC5 is composed of an atypical CARD and lacks an acidic activation domain. NLRC5 also contains a much larger C-terminal LRR …

Jun 14, 2024 · NLRC5 is an innate immune sensor that drives inflammatory cell death in response to NAD+ depletion. NLRC5 interacts with NLRP12 and PANoptosome components to form a …