NKCC1 has been identified in Sertoli cells, spermatocytes, and spermatids in the male reproductive system. [14] NKCC1 function appears to be critical for spermatogenesis, as …

Among the electroneutral Na+-dependent chloride transporters, NKCC1 had until now evaded identification as a protein causing human diseases. The closely related SLC12A transporters, …

This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters.

We provide here the first properly controlled analysis of NKCC1 protein expression in various cell types of the mouse brain using custom-made antibodies and an NKCC1 knock-out validated …

Feb 21, 2020 · NKCC1 is an intensively studied member of the CCC family and plays fundamental roles in regulating trans -epithelial ion movement, cell volume, chloride homeostasis and …

Jul 31, 2019 · The cryo-EM structure of the zebrafish cation–chloride cotransporter NKCC1 reveals the domain organization, ion translocation pathway, ion-binding sites and key residues …

Mar 25, 2018 · NKCC1 is involved in Cl--driven fluid secretion in many exocrine glands, such as sweat, lacrimal, salivary, stomach, pancreas, and intestine. NKCC1 is also involved in K + …

Dec 4, 2020 · While functional evidence firmly shows NKCC1-mediated ion transport in immature and diseased neurons, molecular detection of NKCC1 in the brain has turned out to be …

Oct 14, 2022 · Here, we present a 2.6 Å resolution cryo‐electron microscopy structure of human NKCC1 in the substrate‐loaded (Na +, K +, and 2 Cl −) and occluded, inward‐facing state that …

Jan 1, 2024 · Using extensive deep-learning-guided atomistic simulations of NKCC1 models embedded into the membrane, we captured complex dynamical transitions between alternate …