Characterization of a human cell line (NK-92) with ... - PubMed
CD25 (p55 IL-2 receptor) is expressed on about 50% of all cells when tested at 100 U/ml of IL-2 and its expression correlates inversely with the IL-2 concentration. The p75 IL-2 receptor is expressed on about half of the cells at low density irrespective of the IL-2 concentration.
Cytokine engineered NK-92 therapy to improve persistence and …
Methods: To overcome these drawbacks, we developed a novel membrane-bound protein (MBP) technology to express IL-2 on the surface of NK-92 cells (MBP NK) inducing autocrine signal for proliferation without IL-2 supplementation.
NK-92 cells change their phenotype and function when
Sep 1, 2021 · IL-18 causes an increase in IL-2Rα (CD25) expression by NK cells (Leong et al., 2014, Nielsen et al., 2016) and decreases CD16 receptor expression (Nielsen et al., 2016).
A Novel CAR Expressing NK Cell Targeting CD25 With the …
May 14, 2021 · In the current study, an anti-CD25 CAR was designed and evaluated by comprehensive in silico analyses. Then, using lentiviral transduction system, NK-92 cell line was engineered to express this anti-CD25 CAR construct.
A Novel CAR Expressing NK Cell Targeting CD25 With the
May 14, 2021 · In the current study, an anti-CD25 CAR was designed and evaluated by comprehensive in silico analyses. Then, using lentiviral transduction system, NK-92 cell line was engineered to express this anti-CD25 CAR construct.
Frontiers | A Novel CAR Expressing NK Cell Targeting CD25 With …
May 14, 2021 · In the current study, an anti-CD25 CAR was designed and evaluated by comprehensive in silico analyses. Then, using lentiviral transduction system, NK-92 cell line was engineered to express this anti-CD25 CAR construct.
May 14, 2021 · In the current study, an anti-CD25 CAR was designed and evaluated by comprehensive in silico analyses. Then, using lentiviral transduction system, NK-92 cell line was engineered to express this anti-CD25 CAR construct.
Natural killer cells: the immune frontline against circulating tumor ...
6 days ago · Natural killer (NK) play a key role in controlling tumor dissemination by mediating cytotoxicity towards cancer cells without the need of education. ... (FOXP3 + CD25 + CD4 +) involved in immunomodulation and self-tolerance. ... [89,90,91,92]. However, under the influence of the tumor microenvironment, these neutrophils can be converted into a ...
Leukoreduction filter derived NK cells offer a promising source for …
2 days ago · Notably, NK-92 cells exhibit stable CAR expression but are marked by limitations such as the absence of CD16 and NKp44 expression. Additionally, ...
Discovery of a novel natural killer cell line with distinct ...
Human natural killer (NK) cell lines serve as an attractive source for adoptive immunotherapy, but NK-92 remains the only cell line being assessed in the clinic. Here, we established a novel NK cell line, NK101, from a patient with extra-nodal ...