NF-κB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states.

Mar 30, 2025 · NFKB2 (Nuclear Factor Kappa B Subunit 2) is a Protein Coding gene. Diseases associated with NFKB2 include Immunodeficiency, Common Variable, 10 and Common Variable Immunodeficiency. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Cytosolic sensors of pathogen-associated DNA.

Gene ID: 4791, updated on 8-Feb-2025. This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function.

May 1, 2004 · NFKB2, which encodes p100 and p52, and BCL3, which encodes a member of the IκB family, are involved in chromosomal translocations that are found in various forms of chronic lymphocytic leukaemia...

Jan 4, 2025 · Novel NFKB2 Pathogenic Variants in Two Unrelated Patients with Common Variable Immunodeficiency. Title: Novel NFKB2 Pathogenic Variants in Two Unrelated Patients with Common Variable Immunodeficiency. NF-kappaB/p52 augments ETS1 binding genome-wide to promote glioma progression.

Jun 5, 2017 · NF-κB (nuclear factor-κB) activation is mediated by two main signalling pathways, the canonical and non-canonical pathways, which differ in both signalling mechanisms and biological functions.

Oct 22, 2024 · According to the resulting molecular consequences, NFKB2 mutations can be assigned into 3 distinct protein-defect types: (1) early truncations with p100 and p52 levels reduced to 50%; (2) central truncations with p100 levels reduced to 50% and immediate expression of p52-like proteins; and (3) CTD defects

NF-κB1 has a distinct function from NF-κB2, and is important in controlling lymphocyte and macrophage function in immune and inflammatory responses. In contrast with p100, p105 is constitutively processed to p50.

NFKB1 (164011) and NFKB2 encode p105 and p100 proteins that are processed to produce the active p50 and p52 NF-kappa-B subunits, respectively. However, the p100 and p105 proteins serve regulatory functions and should not be considered exclusively as precursor forms.

Jan 4, 2025 · Clinical resource with information about NFKB2, Immunodeficiency, common variable, 10, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.