Jan 30, 2024 · Neurofibromatosis type 2 (NF2) is a rare autosomal dominant neurocutaneous disorder (phakomatosis) manifesting as a development of multiple CNS tumors. Unlike neurofibromatosis type 1 (NF1) , it is not associated with neurofibromas.

Jun 24, 2022 · NF2 surveillance includes cutaneous, ophthalmic, audiologic, and neurologic evaluations with baseline brain MRI, including thin sections through the internal auditory canal. Regardless of symptoms, surveillance MRI is performed for intracranial and spinal tumors.

The working group reviewed the existing literature on the use of WB-MRI in patients with NF1, NF2, and SWN to evaluate differences in image acquisition (including magnet strengths, imaging planes, and 2D vs 3D approaches); assess the feasibility, reproducibility, and diagnostic accuracy of WB-MRI in people with NF; and evaluate the benefits of ...

Sep 18, 2021 · Neurofibromatosis (NF) Neurofibromatoses ( NF ) comprise a number of clinically and genetically distinct inherited conditions that carry a high risk of tumor formation. They fall under the wider classification of phakomatoses .

Neurofibromatosis type 2, or NF2, is a condition that causes tumors to arise on nerves, particularly those in the skull and spine, though other nerves can be affected. Vestibular schwannomas (also called acoustic neuromas) are tumors that occur in most people with NF2; they affect the nerves that help with balance and hearing.

Cranial and whole spine magnetic resonance imaging showed bilateral vestibulocochlear schwannoma, multiple meningiomas, and one intramedullary tumor. Based on clinical and imaging findings the diagnostic of neurofibromatosis type 2 was made. Introduction. Neurofibromatosis type 2 is a rare disease, with incidence of 1 in 33,000 to 40,000 [1,2].

on WB-MRI, an emerging technology for assessing disease in patients with neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN), to recommend opti-mal image acquisition and analysis methods to enable WB-MRI as an endpoint in …

This review will discuss the imaging appearance of NF1, NF2, and SWN and highlight the important role that imaging plays in informing management decisions in people with tumors associated with these syndromes.

Aug 16, 2016 · Results: WB-MRI at 1.5T or 3.0T is feasible for image acquisition. Short tau inversion recovery (STIR) sequence is used in all investigations to date, suggesting consensus about the utility of this sequence for detection of WB tumor burden in people with NF.

Feb 7, 2025 · If they notice any of the following, an MRI is necessary for NF2 diagnosis confirmation: Optic Tumor Pressure (Papilledema ): An eye exam indicates tumor pressure on the eyes; Juvenile Cataracts: Juvenile cataracts is a common eye issue at birth or shortly after for individuals with NF2.