NF-κB - Wikipedia
NF-κB waits for activation in the cytosol, complexed with the inhibitory protein IκBα. Various extracellular signals can enter the cell via membrane receptors and activate the enzyme IκB kinase (IKK).
NF-κB signaling in inflammation | Signal Transduction and
Jul 14, 2017 · The activation of NF-κB involves two major signaling pathways, the canonical and noncanonical (or alternative) pathways, both being important for regulating immune and inflammatory...
The Nuclear Factor NF-κB Pathway in Inflammation - PMC
The nuclear factor NF-κB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-κB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules.
NF-κB in biology and targeted therapy: new insights and …
Mar 4, 2024 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We investigate the...
Targeting NF-κB pathway for the therapy of diseases: mechanism and ...
Sep 21, 2020 · NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is activated by various stimuli, transducing a quick but transient transcriptional activity,...
NF-κB signaling in inflammation - PubMed
In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.
New insights into NF-κB regulation and function - PMC
Ubiquitination additionally plays critical roles in activation of the noncanonical pathway that regulates NF-κB via signal-induced processing of NF-κB2 p100. New research has also identified several novel regulatory proteins that control the transcriptional activity of nuclear NF-κB.
NF-kB pathway overview | Abcam
Learn about NF-κB family structure and signaling via canonical and non-canonical pathways. What is the NF-κB family? In mammals, the NF-κB family is composed of five related transcription factors: p50, p52, RelA (p65), c-Rel, and RelB 1,2.
NF-kappaB Signaling Pathways in Neurological Inflammation: A …
The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism for the cells in response to a wide variety of stimuli linking ...
NF-κB Signaling | Cell Signaling Technology
4 days ago · In the classical (or canonical) pathway, NF-κB/Rel proteins are bound and inhibited by IκB proteins. Proinflammatory cytokines, LPS, growth factors, and antigen receptors activate an IKK complex (IKKβ, IKKα, and NEMO), which phosphorylates IκB proteins.