NCG mice are triple immunodeficient and lack functional/mature T, B, and NK cells, and have reduced macrophage and dendritic cell function. These animal models have the ability to host …

Charles River currently offers the NCG mouse as part of our immune humanized mouse portfolio. We offer two varieties of humanized mice: HuCD34 NCG Mice – These NCG mice are …

Uniquely created using CRISPR-Cas9 technology to alter to the Prkdc and Il2rg genes, the NCG mouse is the first CRISPR-generated immunodeficient model Charles River has to offer.

Take a look at our Charles River Hu-MouseTM portfolio (HuPBMC-NCG and HuCD34-NCG) to see if they’re a fit for your research, or create your own humanized mouse model using our …

NCG mice are ideal for human graft colonization, cell line-derived xenograft (CDX) and patient-derived xenograft (PDX) models. Learn more about the applications and advantages of the …

NCG-M is a triple-immunodeficient NCG mouse expressing three human cytokines (IL3, GM-CSF (CSF2) and SCF (KITLG)). These cytokines support the stable engraftment of multiple …

The NCG triple immunodeficient mice on a NOD/Nju background lack functional/mature T, B, and NK cells, and have reduced macrophage and dendritic cell function. This study characterized …

Peripheral blood was collected from immune humanized mice to examine human cell populations. Results Humanized NCG-X mice had similar levels of engraftment of human CD45+ cells as …

NCG mice are triple immunodeficient and lack functional/mature T, B, and NK cells, and have reduced macrophage and dendritic cell function.

Nov 13, 2019 · Human HSCs (CD34+) could reconstitute human T but not NK cells in NCG mice. The cytokine Interleukin 15 (IL-15) plays a critical role in the generation of NK cells from HSCs.