Taken together, our current study demonstrates that supplement of NAC in drinking water is capable of suppressing inflammation, modulating glucose and lipid metabolism, and stimulating thermogenic gene expression in HFD-fed mice, consequently preventing mice from diet-induced obesity and obesity-associated liver steatosis and insulin resistance.

Jan 24, 2020 · To that end, we tested the efficacy of oral treatment with NAC in JAK2 V617F knockin mice with respect to their lifespan, thrombosis, and parameters such as blood counts, splenomegaly, and tissue pathologies. We found that NAC reduces thrombosis in these mice via inhibition of PLA and NET formation.

Feb 23, 2017 · We investigated whether NAC, without concurrent plasma exchange and immunosuppressive therapy, is effective in preventing and resolving TTP signs, using well-established murine and baboon models for TTP. In mice, prophylactic administration of NAC was effective in preventing severe TTP signs.

The failure of NAC given at low concentration to improve glucose tolerance in KK-Ay mice, despite reducing serum lipid peroxidation, emphasizes the complexity of NAC action.

Mar 7, 2022 · Results showed that mice receiving GlyNAC supplementation (1) lived 24% longer than control mice; (2) improved/corrected impaired GSH synthesis, GSH deficiency, OxS, mitochondrial dysfunction, abnormal mitophagy and nutrient-sensing, and genomic-damage.

Nov 3, 2024 · We characterized extra hepatic bile ducts (EHBD)s at various ages from 2 to 40 weeks old FVB/N and Mdr2 −/− mice. We examined the therapeutic potential of local NAC ex vivo using EHBD explants at...

The main findings of this study were that supplementation with NAC resulted in the following: 1) improved motor coordination and spatial memory in 6-mo-old mice, but not in 12- or 24-mo-old mice; 2) impaired cognitive flexibility in 24-mo-old mice; 3) reversed age-related declines in walking initiation; and 4) had no effect at any age on body ...

Jan 28, 2019 · In this study, we examined the effect of daily NAC administration on NTG-like retinal degeneration in EAAC1 and GLAST KO mice.

Jan 15, 2017 · NAC modulates antioxidant, glutamatergic, inflammatory and neurotrophic pathways in the central nervous system, all of which are relevant to anxiety pathology. We evaluated the effects of NAC in mice models commonly used to …

NAC treatment significantly lowered HFD-induced macrophage infiltration, and enhanced adiponectin gene expression, resulting in reduced hyperglycemia and hyperinsulinemia, and improvement of insulin resistance.