Ever since identification of the first N7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between N7-guanine adducts and exposure, mutagenesis, and other biological endpoints.

Aug 2, 2009 · Ever since identification of the first N 7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between N 7-guanine adducts and exposure, mutagenesis, and other biological endpoints.

Feb 20, 2012 · After ingestion, AA is converted by P450 into the genotoxic epoxide glycidamide (GA). GA forms DNA adducts, primarily at N7 of guanine (N7-GA-Gua). We performed a dose-response study with AA in female Sprague-Dawley (SD) rats. AA was given orally in a single dosage of 0.1-10 000 μg/kg bw.

We report here on the formation of N7-guanine (N7-Gua) adducts of isoprene-1,2-oxide (IP-1,2-O, 2-ethenyl-2-methyloxirane) and isoprene-3,4-oxide (IP-3,4-O, propen-2-yloxirane). DNA adducts are useful as biomarkers to estimate exposure, as well as to …

Jun 1, 2009 · DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-position of guanine. Ever since identification of the first N7-guanine adduct, several hundred studies on...

Adducts formed at the nucleophilic N7 position of guanine are the most abundant lesions produced by alkylating agents such as ethylene oxide (EO) and propylene oxide (PO).

Aug 2, 2009 · Ever since identification of the first N 7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between N7-guanine adducts and exposure, mutagenesis, and other biological endpoints.

The range of N7-guanine adducts of 0.8–23 adducts/107 nnt in humans, summarized in Table 3, are significantly below the N7-HP-Gua adducts shown to correlate with mutations in Drosophila.

DNA oligonucleotides containing site-specific N7-guanine monoadducts of cisplatin, diepoxybutane, and epichlorohydrin were used as templates for DNA synthesis by two bacterial DNA polymerases and human polymerase β.

Ever since identification of the first N7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between N7-guanine adducts and exposure, mutagenesis, and other biological endpoints.