The tert-butyloxycarbonyl protecting group or tert-butoxycarbonyl protecting group [1] (BOC group) is an acid-labile protecting group used in organic synthesis. The BOC group can be …

A simple and efficient protection procedure is general and regioselective for the preparation of mono-N-Boc, N-Cbz, N-Fmoc or N-Alloc aromatic amines in high yield without affecting …

The N-Boc group is a key topic during chemistry courses. Why? It nicely exemplifies important protecting group concepts and has an interesting deprotection mechanism. 👀 Here’s a 3D …

A simple, efficient, and eco-friendly protocol for the N-Boc protection of the amine moiety in a variety of compounds with di-tert-butyl dicarbonate under water-acetone catalyst-free …

A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)2O/sodium triacetoxyborohydride (STAB) system is reported. …

Apr 25, 2024 · Sequential selective deprotection of N-Boc groups has been demonstrated through temperature control, as exemplified by effective removal of an aryl N-Boc group in the …

Nov 10, 2010 · The kinetics of the HCl-catalyzed deprotection of the Boc-protected amine, thioester 2 to liberate AZD3409 1 have been studied in a mixture of toluene and propan-2-ol. …

Apr 1, 2002 · The intramolecular reactivity of the N-Boc group with nucleophilic (Nu) and with electrophilic (E) moieties is reviewed. The report contains 100 references.

a N-Boc protected peptidomimetic using oxalyl chloride, we observed the concomitant formation of the deprotected N-Boc to form the peptidomimetic with a free amine. We therefore set out to …

Jul 19, 2011 · A simple and efficient procedure for chemoselective mono-N-Boc protection of various structurally diverse amines, amino acids, and peptides with di-tert-butyl dicarbonate …