Aug 18, 2017 · The successful determination of the near-atomic resolution 3D structure of hemoglobin stands as an iconic example of the current capabilities of cryo-EM and the …

Dec 30, 2024 · CD163, a macrophage-specific receptor, plays a critical role in scavenging hemoglobin released during hemolysis, protecting against oxidative effects of heme iron. In the …

Jun 30, 2017 · Here, we report the use of a Volta phase plate in determining the structure of human haemoglobin (64 kDa) at 3.2 Å. Our results demonstrate that this method can be …

Aug 2, 2024 · Native crocodilian Hbs have also proved refractory to crystallisation 17, but improvements in cryo-electron microscopy (cryo-EM) hardware and software now make it …

Aug 18, 2017 · In recent years, cryo-electron microscopy has emerged as a viable alternative and indeed in many cases the preferred approach. It is capable of studying proteins that span a …

We provide data-driven argument for defining and enforcing cryo-EM deposition standards. The appearance of ten high-resolution cryoelectron microscopy (cryo-EM) maps of proteins, …

Sixty years ago, the first protein structure of myoglobin was determined by John Kendrew and his colleagues; hemoglobin followed shortly thereafter. For quite some time, it seemed that only X …

Single-particle cryo-electron microscopy (cryo-EM) is becoming a go-to technique in structural biology. This is due to 1) the broad molecular weight range available for study (50kDa - 16,000 …

Cryo-EM is now able to probe proteins as small as hemoglobin (64 kDa), while avoiding the crystallization bottleneck entirely. The remarkable success of cryo-EM has called into question …

1,510 by cryo-EM. The original three-dimensional electron den-sity map for myoglobin, the first protein to have its structure determined, was computed using X-ray diffraction data extend-ing …