MyoD bHLH - Search

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Cell Press
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Crystal structure of MyoD bHLH domain-DNA complex ... - Cell Press
May 6, 1994 · The crystal structure of a MyoD basic-helix-loop-helix (bHLH) domain-DNA complex has been solved and refined at 2.8 Å resolution. This structure proves that bHLH and …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Crystal structure of MyoD bHLH domain-DNA complex ... - PubMed
May 6, 1994 · The crystal structure of a MyoD basic-helix-loop-helix (bHLH) domain-DNA complex has been solved and refined at 2.8 A resolution. This structure proves that bHLH and …
Author: Philip C.M. Ma, Mark A. Rould, Harold Weintraub, Carl O. Pabo
Publish Year: 1994
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ScienceDirect
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Structural basis of the bHLH domains of MyoD-E47 heterodimer
Sep 17, 2022 · In this study, we determined the crystal structure of the bHLH domain of the MyoD-E47 heterodimer at 2.05 Å. Our structural analysis revealed that MyoD interacts with …
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Studies of MyoD bHLH
PubMed
Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation
The crystal structure of a MyoD basic-helix-loop-helix (bHLH) domain-DNA complex has been solved and refined at 2.8 A resolution. This structure proves that bHLH and bHLH-leucine zipper (bHLH-ZIP) proteins are remarkably similar; it helps us understand subtle differences in binding preferences for t...
Author: P C Ma
Published: 1994/05/06
Keywords: National In…
ScienceDirect
Structural basis of the bHLH domains of MyoD-E47 heterodimer
The basic helix-loop-helix (bHLH) family is one of the most conserved transcription factor families that plays an important role in regulating cell growth, differentiation and tissue development. Typically, members of this family form homo- or heterodimers to recognize specific motifs and activate t...
Published: 2022/09/17
Cited By: 0
Keywords: MyoD; E47…
PubMed
Structural basis of the bHLH domains of MyoD-E47 heterodimer
The basic helix-loop-helix (bHLH) family is one of the most conserved transcription factor families that plays an important role in regulating cell growth, differentiation and tissue development. Typically, members of this family form homo- or heterodimers to recognize specific motifs and activate t...
Author: Jiayun Zhong
Published: 2022/09/17
Keywords: Crystal stru…
National Center for Biotechnology Information
The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist.
In vertebrates, the basic helix-loop-helix (bHLH) protein Twist may be involved in the negative regulation of cellular determination and in the differentiation of several lineages, including myogenesis, osteogenesis, and neurogenesis. Although it has been shown that mouse twist (M-Twist) (i) sequest...
Author: Y Hamamori, …
Published: 1997/11
Publication: Mol Cell B…
ScienceDirect
Article Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation
The crystal structure of a MyoD basic-helix-loop-helix (bHLH) domain-DNA complex has been solved and refined at 2.8 Å resolution. This structure proves that bHLH and bHLH-leucine zipper (bHLH-ZIP) proteins are remarkably similar; it helps us understand subtle differences in binding preferences for t...
Published: 1994/05/06
Cited By: 0
Page Count: 9
PubMed
Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice
The myogenic basic helix-loop-helix (bHLH) genes - MyoD, Myf5, myogenin and MRF4 - exhibit distinct, but overlapping expression patterns during development of the skeletal muscle lineage and loss-of-function mutations in these genes result in different effects on muscle development. MyoD and Myf5 ha...
Author: A Rawls
Published: 1998/7
Keywords: National In…
National Center for Biotechnology Information
Multiple Roles for the MyoD Basic Region in Transmission of Transcriptional Activation Signals and Interaction with MEF2
Establishment of skeletal muscle lineages is controlled by the MyoD family of basic helix-loop-helix (bHLH) transcription factors. The ability of these factors to initiate myogenesis is dependent on two conserved amino acid residues, alanine and threonine, in the basic domains of these factors. It h...
Author: Brian L. Black…
Published: 1998/01
Publication: Mol Cell B…
RCSB PDB
https://www.rcsb.org › structure
RCSB PDB - 1MDY: CRYSTAL STRUCTURE OF MYOD …
Jun 9, 1994 · The crystal structure of a MyoD basic-helix-loop-helix (bHLH) domain-DNA complex has been solved and refined at 2.8 A resolution. This …
Author: Philip C.M. Ma, Mark A. Rould, Harold Weintraub, Carl O. Pabo
Publish Year: 1994
PubMed
https://pubmed.ncbi.nlm.nih.gov
Structural basis of the bHLH domains of MyoD-E47 heterodimer
Sep 17, 2022 · In this study, we determined the crystal structure of the bHLH domain of the MyoD-E47 heterodimer at 2.05 Å. Our structural analysis revealed that MyoD interacts with …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
An overview of the basic helix-loop-helix proteins - PMC
May 6, 2004 · The structure of MyoD (Figure 1a) is typical of many bHLH proteins, comprising two long α helices connected by a short loop, which in the case of MyoD is 8 residues in length. …
People also ask
What is MyoD a bHLH?
MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vertebrate MRF family members include MyoD1, Myf5, myogenin, and MRF4 (Myf6).
MyoD - Wikipedia
en.wikipedia.org
What is the structure of a bHLH protein?
The structure of MyoD (Figure 1a) is typical of many bHLH proteins, comprising two long α helices connected by a short loop, which in the case of MyoD is 8 residues in length. The first helix (H1) includes the basic domain, which makes contact with the major groove of the DNA.
An overview of the basic helix-loop-helix proteins - PMC
pmc.ncbi.nlm.nih.gov
What does bHLH stand for?
1 Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139. The crystal structure of a MyoD basic-helix-loop-helix (bHLH) domain-DNA complex has been solved and refined at 2.8 A resolution.
Crystal structure of MyoD bHLH domain-DNA complex
pubmed.ncbi.nlm.nih.gov
What are the features of the Pho4 bHLH domain?
Two interesting features revealed by the three-dimensional structure of the Pho4 bHLH domain (Figure 1b) are the existence of a short stretch of α-helix in the loop region that links helix H1 to helix H2 and the recognition of DNA bases outside the E-box sequence .
An overview of the basic helix-loop-helix proteins - PMC
pmc.ncbi.nlm.nih.gov
What is the bHLH motif?
The bHLH motif was first observed by Murre and colleagues in two murine transcription factors known as E12 and E47. With the subsequent identification of many other bHLH proteins, a classification was formulated on the basis of their tissue distributions, DNA-binding specificities and dimerization potential .
An overview of the basic helix-loop-helix proteins - PMC
pmc.ncbi.nlm.nih.gov
Which phylogenetic group is bHLH-PAS?
PAS-domain-containing bHLH proteins (bHLH-PAS proteins) form phylogenetic group C. A distinct additional domain, the orange domain, is a 30-residue sequence that is also located carboxy-terminal to the bHLH region, from which it is separated by a short, variable length of sequence.
An overview of the basic helix-loop-helix proteins - PMC
pmc.ncbi.nlm.nih.gov
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nih.gov
https://pubmed.ncbi.nlm.nih.gov
Overlapping functions of the myogenic bHLH genes MRF4 and MyoD …
Overview
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Function
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Wnt signalling can affect MyoD
Coactivators and repressors
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MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. Vert…
Wikipedia · Text under CC-BY-SA license
Wikipedia
https://en.wikipedia.org › wiki › MyoD
MyoD - Wikipedia
MyoD, which was discovered in the laboratory of Harold M. Weintraub, [6] belongs to a family of proteins known as myogenic regulatory factors (MRFs). [7] These bHLH (basic helix loop …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
The basic domain of myogenic basic helix-loop-helix (bHLH) …
In vertebrates, the basic helix-loop-helix (bHLH) protein Twist may be involved in the negative regulation of cellular determination and in the differentiation of several lineages, including …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The basic helix-loop-helix transcription factor Mist1 functions as a ...
Here we describe the characterization of a novel bHLH protein, Mist1, and how it influences MyoD function. We show that Mist1 accumulates in myogenic stem cells (myoblasts) and then …
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