Function of the myogenic regulatory factors Myf5, MyoD
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle …
- Author: Peter S. Zammit
- Publish Year: 2017
MyoD is a 3D genome structure organizer for muscle cell identity
Jan 11, 2022 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the …
Effects of Myogenin on Expression of Late Muscle …
MyoD and myogenin (Myog) recognize sets of distinct but overlapping target genes and play different roles in skeletal muscle differentiation. MyoD is sufficient for near-full expression of early targets, while Myog can only partially enhance …
Function of the myogenic regulatory factors Myf5, MyoD, …
Dec 1, 2017 · Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …
- Author: Peter S. Zammit
- Publish Year: 2017
Distinct Activities of Myf5 and MyoD Indicate Separate …
We find that MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without Pol II recruitment or robust …
- Author: Melissa L. Conerly, Zizhen Yao, Jun Wen Zhong, Mark Groudine, Stephen J. Tapscott, Stephen J. Tapsco...
- Publish Year: 2016
Global and gene-specific analyses show distinct roles for Myod …
Our findings indicate that Myod and Myog have distinct regulatory roles at a similar set of target genes. At genes expressed throughout the program of myogenic differentiation, Myod can bind …
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Human myotube formation is determined by …
MymX and MymK expression ought to be tightly controlled for proper multinucleations of myoblasts in coordination with differentiation program. Our functional studies of MyoD, MyoG, and other MRFs highlight the distinct …
The Myogenic Regulatory Factors, Determinants of Muscle …
The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and …
Muscle regeneration controlled by a designated DNA dioxygenase
May 25, 2021 · Tet2 activates transcription of the key differentiation modulator Myogenin (MyoG) by actively demethylating its enhancer region. Re-expressing of MyoG in Tet2 KO myoblasts …
Differential modulation of cell cycle progression distinguishes …
Feb 18, 2013 · Molecular characterization of two of the MRFs (MyoD and Myog) suggests an important distinction between these factors, whereby MyoD establishes an open chromatin …
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