Myod1 and GR coordinate myofiber-specific transcriptional enhancers
May 7, 2021 · Here, we investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic elements. Our results show that Myod1 is bound to …
MyoD induced enhancer RNA interacts with hnRNPL to activate ... - Nature
Dec 19, 2019 · Master transcription factor MyoD is crucial in activating eRNA production. Super enhancer (se) generated seRNA-1 and -2 promote myogenic differentiation in vitro and in vivo. …
Promoter-Specific Regulation of MyoD Binding and Signal …
Oct 12, 2001 · Signal transduction pathways, rather than acting globally on all MyoD-regulated genes, can regulate the activity of MyoD at restricted subsets of promoters, establishing …
MyoD is a 3D genome structure organizer for muscle cell identity
Jan 11, 2022 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the …
GEP constitutes a negative feedback loop with MyoD and acts as …
The GEP expression during myoblast fusion was a consequence of MyoD transcription factor binding to several E-box (CANNTG) sequences in the 5'-flanking regulatory region of GEP …
Function of the myogenic regulatory factors Myf5, MyoD ... - PubMed
Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle …
MyoD-Induced Trans-Differentiation: A Paradigm for Dissecting …
The discovery of the skeletal muscle-specific transcription factor MyoD represents a milestone in the field of transcriptional regulation during differentiation and cell-fate reprogramming. MyoD …
MyoD and the transcriptional control of myogenesis
Aug 1, 2005 · This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to …
MyoD- and nerve-dependent maintenance of MyoD expression in …
This MyoD expression is regulated by innervation and muscle activity, which act both positively and negatively on several separable regulatory elements in the MyoD gene to fine tune MyoD …
Skeletal muscle-secreted DLPC orchestrates systemic energy
Nov 30, 2023 · By performing lipidomic analysis in muscle-conditioned medium and serum, we identify 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) as a muscle-released lipid that is …
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