MyoD, also known as myoblast determination protein 1, [5] is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, [6] belongs to a family of proteins known as …

Jan 11, 2022 · Pioneer transcription factors (TFs) have been proposed to act as protein anchors to orchestrate cell type-specific 3D genome architecture. MyoD is a pioneer TF for myogenic lineage specification.

Mar 30, 2025 · MYOD1 (Myogenic Differentiation 1) is a Protein Coding gene. Diseases associated with MYOD1 include Congenital Myopathy 17 and Myopathy, Centronuclear, 1.Among its related pathways are Signaling by TGFBR3 and Signaling by TGFB family members.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development.

The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embr …

MyoD is a master transcription regulator belonging to the basic-helix-loop-helix protein family, crucial for the terminal differentiation of skeletal muscle and involved in myofibroblast presence during tissue repair/fibrosis. AI generated definition based on: European Journal of …

MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle ...

MYOD is a master regulator of the skeletal myogenic program. But what regulates expression of Myod? More than 20 years ago, studies established that Myod expression is largely controlled by just two enhancer regions located within a region 24 kb upstream of …

The discovery of the skeletal muscle-specific transcription factor MyoD represents a milestone in the field of transcriptional regulation during differentiation and cell-fate reprogramming. MyoD was the first tissue-specific factor found capable of ...

Fig. 1 MyoD regulates A/B compartment switching and contact domain boundary (CDB) formation in muscle cells. a Association of MyoD-binding peaks at promoter regions and related gene...