Mar 30, 2025 · Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity).

May 16, 2018 · Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow.

Class I Myosins are a subfamily of motor proteins with ATPase activity and a characteristic structure conserved in all myosins: A N-Terminal Motor Domain, a central Neck and a C terminal Tail domain. Humans have eight genes for these myosins.

Aug 16, 2019 · Here we show that unconventional myosin-I MYO1D functions to hold members of the EGFR family (except ErbB3) at the plasma membrane. MYO1D binds only with unphosphorylated EGFRs and anchors...

Apr 27, 2022 · Myosin 1D, a branched actin-associated motor protein, drives coalescence of small nanoscale p62 bodies into large micron-scale condensates along the branched actin network.

The C-terminal end region of the MYO1D tail domain containing a β-meander motif is critical for direct binding with kinase domain of the EGFR family, and expression of the tail domain alone suppresses the oncogenic action of full-length MYO1D.

Myosin-I motors are generally classified into short-tailed (Myo1a, Myo1b, Myo1c, Myo1d, Myo1g and Myo1h) or long-tailed (Myo1e, Myo1f) groups based on the presence of additional glycine-rich (TH2) and SH3 (TH3) domains in the long-tailed isoforms.

Jan 5, 2025 · Title: Identification of a novel MYO1D variant associated with laterality defects, congenital heart diseases, and sperm defects in humans. Top single-nucleotide polymorphism rs379123 in MYO1D is located within genes that function in cell-cell signaling and cell migration.

Identification of a novel MYO1D variant associated with laterality defects, congenital heart diseases, and sperm defects in humans. Top single-nucleotide polymorphism rs379123 in MYO1D is located within genes that function in cell-cell signaling and cell migration.

MYO1D is an unconventional myosin that acts as an actin-based motor protein with ATPase activity. It plays a crucial role in endosomal protein trafficking, particularly in the transfer of cargo proteins from early to recycling endosomes.