Nov 24, 2005 · Neuroblastoma is a childhood cancer with considerable morbidity and mortality. Tumor-derived biomarkers may improve risk stratification. We screened 915 samples of …

Sep 30, 2010 · The current study shows that the majority of infants and some children who have advanced neuroblastoma without MYCN amplification can be cured with substantially reduced …

Jun 12, 2008 · We observed a significant association between neuroblastoma and the common minor alleles of three consecutive single-nucleotide polymorphisms (SNPs) at chromosome …

Apr 28, 2022 · Here we show that MYCN induces massive lipid peroxidation on depletion of cysteine, the rate-limiting amino acid for glutathione (GSH) biosynthesis, and sensitizes cells …

MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor …

Dec 1, 2024 · New findings show that MYC proteins have novel oncogenic functions that are tumor-promoting and go beyond the regulation of gene expression.

Jan 27, 2021 · Dysregulated expression of the transcription factor MYCN is frequently detected in nervous system tumors such as childhood neuroblastoma. Here, gene amplification of …

Apr 17, 2024 · In MYCNA tumors, the extremely high MYCN level promotes glycolytic metabolism, a feature that is important for cancer cell growth as well as for the maintenance …

Feb 25, 2021 · Our work investigated in details the relationship of MYCN with the immune system, finding a correlated immune-suppressive phenotype in neuroblastoma (NB) and different …

Somatic mutations in MYCN have been identified across various tumors, playing pivotal roles in tumorigenesis, tumor progression, and unfavorable prognoses. Despite its established …