L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. [5][6] MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.

Mar 30, 2025 · MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCL include Hematologic Cancer and Lower Lip Cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYCN.

Our aim was to detect MYCL1 amplification, L-Myc and c-Myc expression, and investigate clinicopathological characteristics and survival status in patients with surgically resected SCLC.

MYCL1 Amplification and Expression of L-Myc and c-Myc in Surgically Resected Small-Cell Lung Carcinoma. These results suggest that Mycl1 expression might be useful as a biomarker to predict prognosis and is a promising therapeutic target for patients with gastric cancer.

Jun 18, 2021 · Our aim was to detect MYCL1 amplification, L-Myc and c-Myc expression, and investigate clinicopathological characteristics and survival status in patients with surgically resected SCLC.

Another MYC family member, L- myc (MYCL1), was found to be amplified in small cell lung carcinomas (Nau et al. 1985). Therefore all three vertebrate MYC family genes (MYC, MYCN, and MYCL1) are linked to the etiology of human cancers. Figure 1 summarizes several modes of MYC gene family deregulation.

Jan 24, 2015 · Multivariate analysis showed that Mycl1 expression was an independent prognostic factor of gastric cancer (P=0.009). These results suggest that Mycl1 expression might be useful as a biomarker to predict prognosis and is a promising therapeutic target for patients with gastric cancer.

Mar 5, 2024 · MYCL1 is the target of hsa-miR-1827. A rs3134615 G>T SNP in the 3'-UTR altered regulation of MYCL1 expression. This SNP was associated with increased susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827.

Feb 5, 2024 · MYCL promotes the progression of triple‑negative breast cancer by activating the JAK/STAT3 pathway. Targeted silencing of MYCL1 by RNA interference inhibits migration and invasion of MGC-803 gastric cancer cells. Expression …

The MYCL1 gene encodes the L-myc-1 proto-oncogene protein, a basic helix-loop-helix (bHLH) transcription factor implicated in lung cancer. It interacts with MAX.