An enhancer RNA recruits MLL1 to regulate transcription of Myb
Sep 26, 2023 · Myrlin interacts with the MLL1 complex. Myrlin CRISPRi compromised MLL1 occupancy in the Myb locus, decreasing CDK9 and RNA Pol II binding and resulting in Pol II …
c-Myb Functions as a Co-Activator of MLL1 through Menin, and …
Nov 16, 2007 · Again, using an immunoprecipitation strategy we found that c-Myb is associated with MLL1, WDR5, RbBp5, and Ash2L, which are previously identified members of a multi …
Structure, function and inhibition of critical protein–protein ...
NMR structure of KIX-c-Myb-MLL1 ternary complex (PDB: 2AGH) and compounds inhibiting the MLL1-CBP interaction. a Overview of MLL1 peptide binding to KIX-c-Myb complex. MLL1 is …
C-Myb Associates with MLL1 through Menin, Augments MLL1's …
Nov 20, 2009 · We demonstrated in vitro with purified proteins and an H3 peptide, that c-Myb contributed to the HMT activity of the MLL1 complex. In leukemia patients being treated with a …
An enhancer RNA recruits KMT2A to regulate transcription of Myb
This work clearly shows that Myrlin eRNA directly participates in activating Myb transcription via KMT2A/MLL1 recruitment in MEL cells. We showed that Myrlin may help to recruit or stabilize …
Two decades of leukemia oncoprotein epistasis: the MLL1 …
MLL1, located on human chromosome 11, is disrupted in distinct recurrent chromosomal translocations in several leukemia subsets. Studying the MLL1 gene and its oncogenic …
Sep 26, 2023 · Myrlin CRISPRi compromised MLL1 occupancy in the Myb locus, decreasing CDK9 and RNA Pol II binding and resulting in Pol II pausing in the Myb first exon/intron. Thus, …
An enhancer RNA recruits MLL1 to regulate transcription of Myb
Oct 12, 2023 · Myrlin and Myb are coordinately regulated during erythroid differentiation. Myrlin TSS deletion using CRISPR/Cas9 reduced Myrlin and Myb expression and LDB1 complex …
c-Myb Functions as a Co-Activator of MLL1 through Menin, and …
Nov 16, 2007 · We hypothesize that in the case of MLL1, this interaction contributes to leukemic transformation of hematopoietic cells, and may more broadly contribute to malignant …
C-Myb Associates with MLL1 through Menin, Augments MLL1's …
Nov 20, 2009 · C-Myb Associates with MLL1 through Menin, Augments MLL1's H3K4 Methylation Activity, and Regulates Hoxa9 and Meis1 Gene Expression in Primary Human Leukemia Cells.