MuSK (for Muscle-Specific Kinase) [1] is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction. [2] . It is activated by a nerve-derived proteoglycan called agrin, [3] which is similarly also required for neuromuscular junction formation. [4]

MuSK (muscle-specific kinase) is a receptor tyrosine kinase that plays a central signaling role in formation of neuromuscular junctions (NMJs). MuSK is activated in a complex spatio-temporal manner to cluster acetylcholine receptors on the ...

The encoded protein may play a role in clustering of the a cetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome.

In this review we describe the clinical aspects that distinguish MuSK MG from AChR MG, review what is known about the role of MuSK in the development and function of the neuromuscular junction, and discuss the data that address how the antibodies to MuSK lead to neuromuscular transmission failure.

Muscle-specific kinase (MuSK) is a single-pass transmembrane protein that has a critical role in signaling between motor neurons and skeletal muscle.

Jan 18, 2020 · Defects in MuSK signaling are the cause of muscle weakness as reported in congenital myasthenic syndromes and myasthenia gravis. This review focuses on recent structure-based analyses of MuSK, Agrin, Lrp4 and Dok-7 interactions and their function during MuSK activation.

Know comprehensive MUSK protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Mar 30, 2025 · MUSK (Muscle Associated Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MUSK include Fetal Akinesia Deformation Sequence 1 and Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency .

Mar 17, 2020 · In the present study we have characterized several immunological parameters of murine MuSK-EAMG and have employed induction of oral tolerance in mouse MuSK-EAMG, by feeding with a recombinant MuSK protein one week before disease induction. Such a treatment has been shown to attenuate MuSK-EAMG.

Jan 18, 2020 · MuSK is a receptor tyrosine kinase crucial for formation of neuromuscular junctions. Activation of MuSK requires Agrin-induced Lrp4 binding and recruitment of Dok-7. MuSK kinase activity has to be tightly regulated for proper signaling. MuSK mutations and autoantibodies obstruct signaling causing muscle disorders.