Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans. [5][6][7] MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance.

Mucin-5AC (MUC5AC) is a major secreted mucin in pathogenic airways. To determine its role in mucus-related airway disorders, Muc5ac -deficient (Muc5ac−/−) and wild-type (Muc5ac+/+) mice were compared in bleomycin-induced pulmonary fibrosis, respiratory syncytial virus (RSV) disease, and ozone toxicity.

Mar 30, 2025 · MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5AC include Dry Eye Syndrome and Biliary Tract Disease. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

Mucin 5AC, also known as MUC5AC, is a type of mucin that is produced by surface goblet cells in various parts of the body, including the stomach, respiratory tract, eye, and cervix. It is involved in the formation of a protective barrier in the stomach and plays a role in certain lung diseases.

Apr 1, 2015 · Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and …

Telmisartan mitigates lipopolysaccharide (LPS)-induced production of mucin 5AC (MUC5AC) through increasing suppressor of cytokine signaling 1 (SOCS1). Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer.

Feb 8, 2025 · Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells. Yamada N, et al. J Hepatobiliary Pancreat Sci, 2010 Nov. PMID 20734208.

Mucin 5AC (MUC5AC) belongs to the subset of 5 secreted gel-forming mucins (MUC2, -5B, -5AC, -6, and -19) which are encoded by a gene cluster located at chromosome 11p15.

Dec 20, 2024 · Mucins 5AC (MUC5AC) and 5B (MUC5B) are the major mucins providing the organizing framework for the airway's mucus gel.

MUC5AC (mucin 5AC, oligomeric gel-forming) and MUC5B (mucin 5B, oligomeric gel-forming) are the predominant secreted polymeric mucins in mammalian airways.