Mucins (/ ˈmjuːsɪn /) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. [1] .

Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production.

The mucins function in limiting the activation of inflammatory responses at the interface with the environment. Deregulation of mucin production has therefore provided an important link between inflammation and cancer.

Mucins are a family of high molecular weight, heavily glycosylated proteins that are classified into 2 groups: membrane-bound mucins (eg, MUC1, MUC3, and MUC4) involved in signal transduction and gel-forming secreted mucins released into the extracellular space (eg, MUC2, MUC5AC, MUC5B and MUC6). 1 At least 18 mucin genes have been cloned to ...

Glycoprotein, rich in carbohydrates, produced by the goblet cells and the subsurface vesicles of the conjunctiva which forms the basis of the mucous layer of the precorneal film.

Mucins are modified in a variety of diseases and this may be due to abberant mucin peptide or glycosylation. Major conclusions: Mucins represent a family of glycoprotein having fundamental roles in mucosal protection and communication with external environment.

Sep 21, 2021 · Generating the barriers that protect our inner surfaces from bacteria and other challenges requires large glycoproteins called mucins. These come in two flavors, gel-forming and transmembrane, all characterized by large highly O-glycosylated mucin ...

Feb 1, 2018 · Mucins are the main structural components of mucus that create a selective protective barrier for epithelial surface and also execute wide range of other physiological functions. Mucins can be classified into two types, namely secreted mucins and membrane bounded mucins.

Aug 8, 2016 · In this Review, we will give a basic overview of mucus, mucins and goblet cells, and explain how each of these contributes to immune regulation in the intestine. Our bodies are continuously exposed...

Aug 9, 2021 · In this Primer, we will take a look at how mucins, the building blocks of mucus, are synthesized, how their expression is regulated and achieved, and how they make crucial contributions to health and disease.