Dec 25, 2024 · MUC20 (Mucin 20, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC20 include Childhood Hepatocellular Carcinoma. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

Feb 8, 2025 · MUC20 is a novel transmembrane mucin expressed by the human corneal and conjunctival epithelia, and suggest that differential expression of MUC20 during differentiation has a role in maintaining ocular surface homeostasis.

Mar 5, 2024 · We evaluated the effect of MUC20 on cuproptosis of PI-resistant MM cells using Co-immunoprecipitation (Co-IP), Seahorse bioenergetic profiling and in vivo assay. This study revealed that the downregulation of Mucin 20 (MUC20) could predict PI …

Jun 20, 2013 · Cumulatively, MUC20 may serve as an important predictor of recurrence and poor outcome for CRC patients. MUC20 overexpression could enhance migration and invasion abilities of CRC cells. Translation of its roles into clinical practice will need further investigation and additional test validation.

MUC20 is a membrane-bound mucin for which minimal research has been conducted compared to other mucins. Xiao et al. is the only group to publish research on MUC20 and its role in CRC [125].

Jul 11, 2018 · These findings suggest that MUC20 knockdown suppresses the malignant phenotypes of PDAC cells at least partially through the inhibition of the HGF/MET pathway and that MUC20 could act as a...

"Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney". J Biol Chem. 279 (3): 1968–79. doi: 10.1074/jbc.M304558200.

In vivo, we examined chemoresistance using MUC20 variant 2 (MUC20v2)-overexpressing non-SRCC cells to construct a xenograft mouse model. Results: We analyzed a comprehensive GC cell line database to identify the specifically expressed genes in gastric SRCC.

After further analyzing, an immune-related biomarker mucin 20 (MUC20, cell surface associated) was identified. MUC20 is a transmembrane mucin secreted by various epithelial cells to form a protecting mucous barrier, which performs a variety of roles ranging from physical protection to the regulation of immunity and cell signaling [10, 11].

In this study, immunohistochemical staining demonstrated that high MUC20 expression correlated with poor progression-free survival and high local recurrence rate of PDAC patients (n 61). The...