In this study, we show that exogenous expression of MUC13 enhances tumorigenic features such as cell growth, colony formation, cell migration and invasion of colon cancer cells. In contrast, …

Mar 1, 2022 · Mucin 13 (MUC13) is a high-molecular-weight transmembrane glycoprotein that is frequently and aberrantly expressed in a variety of epithelial carcinomas, including gastric, …

In this study, we demonstrate that MUC13 protects human colorectal cancer cells from cell death in response to activation of both intrinsic and extrinsic pathways via NF-κB activation and …

Aug 19, 2019 · Here, we report the roles of MUC13 in colonic tumorigenesis and tumor progression. High-MUC13 expression is associated with poor survival in two independent …

Oct 25, 2018 · Results: MUC13 is secreted from cancer cell lines, with highest levels found in ovarian cancer cell lines. MUC13 levels in human sera were significantly increased in patients …

May 25, 2001 · Transmembrane mucins are glycoproteins involved in barrier function in epithelial tissues. To identify novel transmembrane mucin genes, we performed a tblastn search of the …

The results of this study, for the first time, suggest functional roles of MUC13 in colon cancer progression and provide information regarding the regulation of MUC13 expression via …

Nov 14, 2012 · MUC1 and MUC13 both regulate chemokine secretion in gastrointestinal epithelial cells through a nuclear factor-κB-dependent pathway, although MUC13 modulation could also …

Studies have shown that MUC13 overexpression can disrupt normal cellular polarity, leading to the acquisition of malignant traits. Furthermore, MUC13 has been associated with increased …

Jul 11, 2016 · Here, we report that MUC13 prevents colorectal cancer cell death by promoting two distinct pathways of NF-kB activation, consequently upregulating BCL-X L. MUC13 promoted …